2017
Table of Contents
Table of Contents
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185. Parker, C. G.; Kuttruff, C. A.; Galmozzi, A.; Jørgensen, L.; Yeh, C-. H.; Hermanson, D. J.; Wang, Y.; Artola, M.; McKerrall, S. J.; Josyln, C. M.; Nørremark, B.; Dü nstl, G.; Felding, J.; Saez, E.; Baran, P. S.; Cravatt, B. F. Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs. ACS Cent. Sci. 2017, 3, 1276. -
184. deGruyter, J. N.; Malins, L. R.; Wimmer, L.; Clay, K. J.; Lopez-Ogalla, J.; Qin, T.; Cornella, J.; Liu, Z.; Che, G.; Bao, D.; Stevens, J. M.; Qiao, J. X.; Allen, M. P.; Poss, M. A.; Baran, P. S. CITU: A Peptide and Decarboxylative Coupling Reagent, Org. Lett. 2017, 19, 6196.
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183. Yan, M.; Kawamata, Y; Baran, P. S. Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance. Chem. Rev. 2017, 117, 13230.
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182. Li, C.; Kawamata, Y.; Nakamura, H.; Vantourout, J. C.; Liu, Z.; Hou, Q.; Bao, D.; Starr, J. T.; Chen, J.; Yan, M.; Baran, P. S. Electrochemically Enabled, Nickel-Catalyzed Amination. Angew. Chem. Int. Ed. 2017, 56, 13088.
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181. Yan, M.; Kawamata, Y.; Baran, P. S. Synthetic Organic Electrochemistry: Calling All Engineers. Angew. Chem. Int. Ed. Accepted
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180. Trammell, R.; See, Y.; Herrmann, A. T.; Xie, N.; Díaz, D. E.; Siegler, M. A.; Baran, P. S.; Garcia-Bosch, Isaac. Decoding the Mechanism of Intramolecular Cu-Directed Hydroxylation of sp3 C−H Bonds. J. Org. Chem. 2017, 82, 7887.
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179. deGruyter, J. N.; Malins, L. R.; Baran, P. S. Residue-Specific Peptide Modification: A Chemist’s Guide, Biochemistry, 2017, 56, 3863.
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178. Smith, J. M.; Qin, T.; Merchant, R. R.; Edwards, J. T.; Malins, L. R.; Liu, Z.; Che, G.; Shen, Z.; Shaw, S. A.; Eastgate, M. D.; Baran, P. S. Decarboxylative Alkynylation, Angew. Chem. Int. Ed. 2017, 56, 1–6
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177. Kawamata, Y.; Yan, M.; Liu, Z.; Bao, D. -H.; Chen, J.; Starr, J.; Baran, P. S. Scalable, Electrochemical Oxidation of Unactivated C–H Bonds, J. Am. Chem. Soc. 2017, 139, 7448−7451
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176. Edwards, J. T.; Merchant, R. R.; McClymont, K. S.; Knouse, K. W.; Qin, T.; Malins, L. R.; Vokits, B.; Shaw, S. A.; Bao, D.-H.; We, F.-L.; Zhou, T.; Eastgate, M. D.; Baran, P. S. Decarboxylative Alkenylation, Nature, 2017, 545, 213-218
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175. Li, C.; Wang, J.; Barton, L. M.; Yu, S.; Tian, M.; Peters, D. S.; Kumar, M.; Yu, A. W.; Johnson, K. A.; Chatterjee, A. K.; Yan, M.; Baran, P. S. Decarboxylative Borylation, Science, 2017, 356, eaam7355
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174. Malins, L. R.; deGruyter, J. N.; Robbins, K. J.; Scola, P. M; Eastgate, M.; Ghadiri, M. R.; Baran, P. S. Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products, J. Am. Chem. Soc. 2017, 139, 5233-5241.
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173. Sandfort, F.; O'Neill, M. J.; Cornella, J.; Wimmer, L.; Baran, P. S. Alkyl-(Hetero)Aryl Bond Formation via Decarboxylative Cross-Coupling: A Systematic Analysis, Angew. Chem. Int. Ed. 2017 56, 3319-3323.
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172. Lopchuk, J. M.; Fjelbye, K.; Kawamata, Y.; Malins, L. R.; Pan, C.-M.; Gianatassio, R.; Wang, J.; Prieto, L.; Bradow, J.; Brandt, T. A.; Collins, M. R.; Elleraas, J.; Ewanicki, J.; Farrell, W.; Fadeyi, O. O.; Gallego, G. M.; Mousseau, J. J.; Oliver, R.; Sach, N. W.; Smith, J. K.; Spangler, J. E.; Zhu, H.; Zhu, J.; Baran, P. S. Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity, J. Am. Chem. Soc. 2017, 139, 3209-3226.
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171. Lo, J. C.; Kim, D.; Pan, C.-M.; Edwards, J. T.; Yabe, Y.; Gui, J.; Qin, T.; Gutiérrez, S.; Giacoboni, J.; Smith, M. W.; Holland, P. L.; Baran, P. S. Fe-Catalyzed C–C Bond Construction from Olefins via Radicals, J. Am. Chem. Soc. 2017, 139, 2484-2503.
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170. Chu, H.; Smith, J. M.; Felding, J.; Baran, P. S. Scalable Synthesis of (–)-Thapsigargin, ACS Cent. Sci. 2017, 3, 47-51.
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169. Qin, T.; Malins, L. R.; Edwards, J. T.; Merchant, R. R.;. Novak, A. J. E.; Zhong, J. Z.; Mills, R. B.; Yan, M.; Yuan, C.; Eastgate,, M. D.; Baran P. S. Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms. Angew. Chem. Int. Ed. 2017, 56, 260.
2016
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168. Tian, M.; Yan, M.; Baran, P. S. 11-Step Total Synthesis of Araiosamines, J. Am. Chem. Soc. 2016, 138, 14234-14237
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167. Yan, M.; Lo, J. C.; Edwards, J. T.; Baran, P. S. Radicals: Reactive Intermediates with Translational Potential, J. Am. Chem. Soc. 2016, 138, 12692-12714
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166. Toriyama, F.; Cornella, J.; Wimmer, L.; Chen, T.-G.; Dixon, D. D.; Creech, G.; Baran, P. S. Redox-Active Esters in Fe-catalyzed C-C Coupling, J. Am. Chem. Soc. 2016, 138, 11132-11135
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165. Cernijenko, A.; Risgaard, R.; Baran, P. S. 11-Step Total Synthesis of (-)-Maoecrystal V, J. Am. Chem. Soc. 2016, 138, 9425-9428
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164. Wang, J.; Qin, T.; Chen, T.-E.; Wimmer, L.; Edwards, J. T.; Cornella, J.; Vokits, B.; Shaw, S. A.; Baran, P. S. Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids, Angew. Chem. Int. Ed. 2016, 55, 9676-9679
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163. Martinez, L. P.; Umemiya, S.; Wengryniuk, S. E.; Baran, P. S. 11-Step Total Synthesis of Pallambins C and D, J. Am. Chem. Soc. 2016, 138, 7536-7539
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162. Yuan, C.; Jin, Y.; Wilde, N. C.; Baran, P. S. Short, Enantioselective Total Synthesis of Highly Oxidized Taxanes, Angew. Chem. Int. Ed., 2016, 55, 8280-8284
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161. Horn, E. J.; Rosen, B. R.; Baran, P. S. Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method, ACS Cent. Sci., 2016, 2, 302-308.
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160. Qin, T.; Cornella, J.; Li, C.; Malins, L. R.; Edwards, J. T.; Kawamura, S.; Maxwell, B. D.; Eastgate, M. D.; Baran, P. S. A General Alkyl-Alkyl Cross-Coupling Enabled by Redox-Active Esters and Alkylzinc Reagents, Science, 2016, 352, 801-805
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159. Horn, E. J.; Rosen, B. R.; Chen, Y.; Tang, J.; Chen, K.; Eastgate, M. D.; Baran, P. S. Scalable and sustainable electrochemical allylic C-H oxidation, Nature, 2016, 533, 78-81
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158. Kawamura, S.; Chu, H.; Felding, J.; Baran, P. S. Nineteen-step total synthesis of (+)-phorbol, Nature, 2016, 532, 90-93
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157. Cornella, J.; Edwards, J. T.; Qin, T.; Kawamura, S.; Wang, J. Pan, C-M.; Gianatassio, R.; Schmidt, M. A.; Eastgate, M. D.; Baran, P. S. Practical Ni-Catalyzed Aryl-Alkyl Cross-Coupling of Secondary Redox-Active Esters, J. Am. Chem. Soc., 2016, 138 (7), pp 2174-2177
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156. Gianatassio, R.; Lopchuk, J. M.; Wang, J.; Pan, C-M.; Malins, L. R.; Prieto, L.; Brandt, T. A.; Collins, M. R.; Gallego, G. M.; Sach, N. W.; Spangler, J. E.; Zhu, H.; Baran, P. S. Strain-release amination, Science, 2016, 351, pp. 241-246
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155. Villaume, M.T.; Sella, E.; Saul, G.; Borzilleri, R. M.; Fargnoli, J.; Johnston, K. A.; Zhang, H.; Fereshteh, M. P.; Dhar, T. G. M.; Baran, P. S. Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate, ACS Cent. Sci., 2016, 2 (1), pp 27-31
2015
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154. See, Y. Y.; Herrmann, A. T.; Aihara, Y.; Baran, P. S. Scalable C-H Oxidation with Copper: Synthesis of Polyoxypregnanes, J. Am. Chem. Soc, 2015, 137, 13776-13779
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153. Jin, Y.; Yeh, C.-H.; Kuttruff, C. A.; Jorgensen, L.; Dunstl, G.; Felding, J.; Natarajan, S. R.; Baran, P. S. C-H Oxidation of Ingenanes Enables Potent and Selective Protein Kinase C Isoform Activation, Angew. Chem. Int. Ed., 2015, 54, 14044-14048
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152. Feng, Y.; Holte, D.; Zoller, J.; Umemiya, S.; Simke, L. R.; Baran, P. S. Total Synthesis of Verruculogen and Fumitremorgin A Enabled by Ligand-Controlled C-H Borylation, J. Am. Chem. Soc, 137, 10160-10163
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151. Dao, H. T.; Li, C.; Michaudel, Q.; Maxwell, B. D.; Baran, P. S. Hydromethylation of Unactivated Olefins, J. Am. Chem. Soc, 2015, 137, 8046-8049
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150. Gui, J.; Pan, C-M.; Jin, Y.; Qin, T.; Lo, J. C.; Lee, B. J.; Spergel, S. H.; Mertzman, M. E.; Pitts, W. J.; La Cruz, T. E.; Schmidt, M. A.; Darvatkar, N.; Natarajan, S. R.; Baran, P. S. Practical Olefin Hydroamination with nitroarenes, Science 2015, 348, 886–891
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149. Michaudel, Q.; Ishihara, Y.; Baran, P. S. Academia–Industry Symbiosis in Organic Chemistry, Acc. Chem. Res. 2015, 48, 712–721
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148. Renata, H.; Zhou, Q.; Dünstl, G.; Felding, J.; Merchant, R. R.; Yeh, C.-H.; Baran, P. S. Development of a Concise Synthesis of Ouabagenin and Hydroxylated Corticosteroid Analogues, J. Am. Chem. Soc. 2015, 137,1330–1340
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146. Maimone, T. J.; Ishihara, Y.; Baran, P. S. Scalable Total Syntheses of (−)-Hapalindole U and (+)-Ambiguine H, Tetrahedron 2015, 71, 3652–3665