Preprints & ASAPs
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7. Imasuen, J. O.; Jiang, B.; Sofiadis, M.; Harper, K. C.; Yamamoto, D.; Imai, T.; Pollatos, A. S.; Neigenfind, P.; Kawamata, Y.; Baran, P. S. Simultaneous Two-Directional Catalytic Radical Cross-Coupling. ChemRxiv 2026, Preprint. -
6. Neigenfind, P.; Kawamata, Y.; Baran, P. S. Simplifying Radical Cross-Coupling by Deleting Redox. ChemRxiv 2026, Preprint.
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5. Nasiri, N.; Baran, P. S. 11-Step Synthesis of (+)-Roussoellatide. ChemRxiv 2026, Preprint.
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4. Jiang, B.; Deng, M.; Kakkis, A.; Cagan, D. A.; Nassir, M.; Cho, Y.; Drexler, D.; Ejemel M.; Evans, H.; Lee, E.; Li, A.; Nam, D.; Parsons, Z.; Thakore, R. R.; Wang, W.; Zheng, B.; Zhu, Y.; Welin, E. R.; Mercer, S.; Zhang, H.; Juneja, J.; Yamazoe, S.; Jordan, N. V.; Schmidt, M. A.; Scola, P. M.; Blackmond, D. G.; Dawson, P.; Baran, P. S. A Kinetics-First Approach Reveals Optimum Vinylaminopyrimidines for Cysteine-Based Antibody Conjugation. ChemRxiv 2026, Preprint.
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3. Pollatos, A. S.; Kawamata, Y.; Baran, P. S. Electrochemistry Goes Mainstream: Applications in Modern Total Synthesis. ChemRxiv 2026, Preprint.
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2. Wang, S.; Cagan, D. A., Tsien, J.; Zhang, J.; Gogula, T.; Murthy, A. V. R.; Nangunoori, S. K.; Boga, G.; Oderinde, M. S.; Turner, A. M.; Hang, H. C.; Kawamata, Y.; Baran, P. S. Highly Chemoselective Access to Alkyl-Sulfur Compounds via N2 Extrusion of Alkyl Hydrazines. Nature 2026, ASAP.
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1. Wang, S.; Cagan, D. A.; Cao, Y.; Vokits, B. P.; Palkowitz, M. D.; Kawamata, Y.; Baran, P. S.; Engle, K. M. Chemoselective Ni-Catalysed Directed C(sp2)–H Alkylation at Low Temperature Using Alkyl Sulfonylhydrazides. Nature Synthesis 2026, ASAP.
2026
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293. Guo, Y.; Li, Y.; Buchberger, B.; Liu, Y.; Capone, C.; Adak, T.; Ojha, S.; Tyler, J. L.; Neigenfind, P.; Nassir, M.; Kawamata, Y.; Aggarwal, V. K.; Baran, P. S. C-Glycoside Synthesis via Radical Cross-Coupling of Glycohydrazides. Nature 2026, 655, 1195–1203.
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292. Neigenfind, P.; Gathmann, C.; Cherney, E. C.; Parker, C. G.; Baran, P. S. Enabling Access to sp3-Enriched Targeted Protein Degraders via Redox-Neutral Radical Cross-Coupling. Angew. Chem. Int. Ed. 2026, 65, 25, e3989307.
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291. Wang, Y.; Sun, J.; Li, Y.; Cagan. D. A.; Ring, O. T.; Zeng, X.; Tsien, J.; Massaro, L.; Smith, J. E.; Orzolek, B. J.; Collins, M. R.; Kawamata, Y.; Baran, P. S. Stereoretentive Radical-Based Alkyl-Alkyl Cross-Coupling. Science 2026, 392, 6802, 1075–1081.
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290. Barnes, G. L.; Rerick, A. L.; Baran, P. S. Radical Retrosynthesis of Natural Products Enabled by Iron-Based Reductive Olefin Coupling. Angew. Chem. Novit. 2026, 2, 1, e70017.
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289. Kurig, N.; Cagan, D. A.; Harper, K. C.; Kawamata, Y.; Blackmond, D. G.; Baran, P. S. Arylhydrazines: Convenient Homogeneous Reductants for Scalable Cross-Coupling. Angew. Chem. Int. Ed. 2026, 65, e9252206.
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288. Massaro, L.; Neigenfind, P.; Feng, A.; Kuehn, G.; Attard, F. C.; DeSanti, A.; Collins, M. R.; Bravo, M.; Twumasi, R. K.; Chen, D.; Bolduc, P. N.; Nicastri, M.; Emmanuel, M. A.; Oderinde, M. S.; Palkowitz, M. D.; Zheng, X.; Hunter, A. C.; Harper, K. C.; Tyrol, C. C.; Mykhailiuk, P. K.; Kawamata, Y.; Baran, P. S. Triply Convergent Ni-Electrocatalytic Assembly of 1,1-Diaryl Cyclobutanes, Azetidines and Oxetanes. Nat. Chem. 2026, 18, 326–334.
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287. Cagan, D. A.; Péter, Á.; Vokits, B. P.; Chan, M.; Baran, P. S.; Blackmond, D. G. Decoding the Nested, Multi-Cycle Mechanism of Ni-Catalyzed Redox-Neutral Cross-Coupling through Temperature Scanning Reaction Calorimetry. J. Am. Chem. Soc. 2026, 148, 1, 677–691.
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286. Rerick, A. L.; Barnes, G. L.; Schneider, F.; Oxenfart, L.; Baran, P. S. Terpenoid Synthesis via Convergent Radical Annulation. Angew. Chem. Int. Ed. 2026, 65, 3, e21852.
2025
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285. Tsien, J.; Péter, Á.; Zeng, X.; Wang, S.; Jiang, B.; Emmanuel, M. A.; Oderinde, M. S.; Bolduc, P. N.; Nicastri, M. C.; Dey, S.; Collins, M. R.; Lee, J. W.; Bravo, M.; Richardson, P. F.; Sach, N. W.; Bernier, L.; Palkowitz, M. D.; Qiao, J. X.; Kawamata, Y.; Baran, P. S. Accelerating Medicinal Chemistry: A C(sp3)-Rich Fragment Toolbox for Redox-Neutral Cross-Coupling. Angew. Chem. Int. Ed. 2025, 64, 51, e202517207.
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284. Attard, F. C.; Slobodianyk, A.; Bychek, R.; Panasiuk, Y.; Neigenfind, P.; Massaro, L.; Gardiner, M. G.; Levterov, V. V.; Baran, P. S.; Mykhailiuk, P. K.; Malins, L. R. Dibromocarbene Addition to Bicyclo[1.1.0]butanes: A Facile Route to Substituted Bicyclo[1.1.0]pentanes. PNAS 2025, 122, 44, e2524130122.
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283. Guo, Y.; Li, Y.; Chen, S.; Wu, Y.; Poll, O.; Ren, Z.; Liu, Z.; Vlkolinsky, R.; Bajo, M.; Prier, C. K.; Xiao, K.-J.; Cravatt, B. F.; Roberto, M.; Baran, P. S. Scalable Total Synthesis of Saxitoxin and Related Natural Products. Nature 2025, 646, 351–357.
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282. Bielecki, M.; Nassir, M.; Sharma, H. A.; Truax, N. J.; Raheja, N.; Thompson, T. M.; El-Hayek Ewing, T.; Melillo, B.; Cravatt, B. F.; Baran, P. S. Enantiocontrolled Azetidine Library Synthesis via Strain-Release Functionalization of 1-Azabicyclobutanes. J. Am. Chem. Soc. 2025, 147, 25, 22209–22218.
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281. Wang, Y.; Bogner, M. M.; Bailey, J. B.; Grant, L. N.; Gembicky, M.; Richardson, P. F.; Baran, P. S. Cobalt-Catalyzed Alkene Hydronitration Enabled by Anomeric Nitroamide. Nat. Cat. 2025, 8, 457–464.
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280. Rodriguez, A. J.; Pokle, M. S.; Barnes, G. L.; Baran, P. S. 10-Step, Gram-Scale Total Synthesis of (–)-Bipinnatin J. J. Am. Chem. Soc. 2025, 147, 20, 16781–16785.
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279. Sharma, H. A.; Bielecki, M.; Holm, M. A.; Thompson, T. M.; Yin, Y.; Cravatt, J. B.; Ware, T. B.; Reed, A.; Nassir, M.; El-Hayek Ewing, T.; Melillo, B.; Bazan, J. F.; Baran, P. S.; Cravatt, B. F. Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors. J. Am. Chem. Soc. 2025, 147, 18, 15554–15566.
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278. Sun, J.; He, J.; Massaro, L.; Cagan, D. A.; Tsien, J.; Wang, Y.; Attard, F. C.; Smith, J. E.; Lee, J. S.; Kawamata, Y.; Baran, P. S. Stereoretentive Radical Cross-Coupling. Nature 2025, 642, 85–91.
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277. Sun, J.; Péter, Á.; He, J.; Tsien, J.; Zhang, H.; Cagan, D. A.; Vokits, B. P.; Peters, D. S.; Oderinde. M. S.; Mandler, M. D.; Richardson, P.; Chen, D.; Palkowitz, M. D.; Raheja, N.; Kawamata, Y.; Baran, P. S. Sulfonyl Hydrazides as a General Redox-Neutral Platform for Radical Cross-Coupling. Science 2025, 387, 1377–1383.
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276. Jafarzadeh, M.; Nassir, M.; Gherardi, L.; Raheja, N.; Kawamata, Y.; Baran, P. S. Electrifying P(V): Access to Polar and Radical Reactivity. Angew. Chem. Int. Ed. 2025, 64, 8, e202421163.
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275. Sun, J.; Wang, S.; Harper, K. C.; Kawamata, Y.; Baran, P. S. Stereoselective Amino Alcohol Synthesis via Chemoselective Electrocatalytic Radical Cross-Couplings. Nature Chem. 2025, 17, 44–53.
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274. Nassir, M.; Gheradi, L.; Redman, R. L.; Jin, Y.; Yao, F.; Yang, Y.; Raheja, N.; Natarajan, A.; Butler, D.; Knouse, K. W.; Baran, P. S. An Improved P(V) Thio-Oligonucleotide Synthesis Platform. Org. Lett. 2025, 27, 1, 97–102.
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273. El-Hayek Ewing, T.; Kurig, N.; Yamaki, Y. R.; Sun, J.; Knowles, T. R.; Gollapudi, A.; Kawamata, Y.; Baran, P. S. Pyrolytic Carbon: An Inexpensive, Robust, and Versatile Electrode for Synthetic Organic Electrochemistry. Angew. Chem. Int. Ed. 2025, 64, 4, e202417122.
2024
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272. He, J.; Yokoi, K.; Wixted, B.; Zhang, B.; Kawamata, Y.; Renata, H.; Baran, P. S. Biocatalytic C–H Oxidation Meets Radical Cross-Coupling: Simplifying Complex Piperidine Synthesis. Science 2024, 386, 6728, 1421–1427.
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271. Obexer, R.; Nassir, M.; Moody, E. R.; Baran, P. S.; Lovelock, S. L. Modern Approaches to Therapeutic Oligonucleotide Manufacturing. Science 2024, 384, 6692, eadl4015.
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270. Laudadio, G.; Neigenfind, P.; Chebolu, R.; Blasczak, V. D.; Maddirala, S. J.; Palkowitz, M. D.; Bolduc, P. N.; Nicastri, M. C.; Puthukanoori, R. K.; Paraselli, B. R.; Baran, P. S. Synthesis of Unnatural Amino Acids via Ni/Ag Electrocatalytic Cross-Coupling. Org. Lett. 2024, 26, 11, 2276–2281.
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269. Smith, B. P.; Truax, N. J.; Pollatos, A. S.; Meanwell, M.; Bedekar, P.; Garrido-Castro, A. F.; Baran, P. S. Total Synthesis of Dragocins A–C via Electrochemical Cyclization. Angew. Chem. Int. Ed. 2024, e202401107 Total Synthesis of Dragocins A−C through Electrochemical Cyclization. Angew. Chem. 2024, 63, 19, e202401107.
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268. Sun, J.; Endo, H.; Emmanuel, M. A.; Oderinde, M. S.; Kawamata, Y.; Baran, P. S. Simplified Modular Access to Enantiopure 1,2-Aminoalcohols via Ni-Electrocatalytic Decarboxylative Arylation. J. Am. Chem. Soc. 2024, 146, 9, 6209–6216.
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267. Gao, Y.; Jiang, B.; Friede, N. C.; Hunter, A. C.; Boucher, D. G.; Minteer, S. D.; Sigman, M. S.; Reisman, S. E.; Baran, P. S. Electrocatalytic Asymmetric Nozaki–Hiyama–Kishi Decarboxylative Coupling: Scope, Applications, and Mechanism. J. Am. Chem. Soc. 2024, 146, 7, 4872–4882.
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266. Rubel, C. Z.; Cao, Y.; El-Hayek Ewing, T.; Laudadio, G.; Beutner, G. L.; Wisniewski, S. R.; Wu, X.; Baran, P. S.; Vantourout, J. C.; Engle, K. M. Electroreductive Synthesis of Nickel(0) Complexes. Angew. Chem. 2024, 63, 2, e202311557.
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265. Gan, X.; Zhang, B.; Dao, N.; Bi, C.; Pokle, M.; Kan, L.; Collins, M. R.; Tyrol, C. C.; Bolduc, P. N.; Nicastri, M.; Kawamata, Y.; Baran, P. S.; Shenvi, R. A. Carbon Quaternization of Redox Active Esters and Olefins by Decarboxylative Coupling. Science 2024, 384, 6691, 113–118.
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264. Schneider, F.; Guo, Y.; Lin, Y-C.; Eberle, K. J.; Chiodi, D.; Greene, J. A.; Lu, C.; Baran, P. S. Total Synthesis of Dynobactin A. J. Am. Chem. Soc. 2024, 146, 10, 6444–6448.
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263. Wang, Y.; Bi, C.; Kawamata, Y.; Grant, L. N.; Samp, L.; Richardson, P. F.; Zhang, S.; Harper, K. C.; Palkowitz, M. D.; Vasilopoulos, A.; Collins, M. R.; Oderinde, M. S.; Tyrol, C. C.; Chen, D.; LaChapelle, E. A.; Bailey, J. B.; Qiao, J. X.; Baran, P. S. Discovery of N–X Anomeric Amides as Electrophilic Halogenation Reagents. Nature Chem. 2024, 16, 1539–1545.
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262. Laudadio, G.; Neigenfind, P.; Peter, A.; Rubel, C. Z.; Emmanuel, M. A.; Oderinde, M. S.; El-Hayek Ewing, T.; Palkowitz, M. D.; Sloane, J. L.; Gillman, K. W.; Ridge, D.; Mandler, M. D.; Bolduc, P. N.; Nicastri, M. C.; Zhang, B.; Clementson, S.; Petersen, N. N.; Martin-Gago, P.; Mykhailiuk, P.; Engle, K. M.; Baran, P. S. Nickel-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers. Angew. Chem. 2024, 136, 8, e202314617.
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261. Neigenfind, P.; Massaro, L.; Peter, A.; Degnan, A. P.; Emmanuel, M. A.; Oderinde, M. S.; He, C.; Peters, D.; El-Hayek Ewing, T.; Kawamata, Y.; Baran, P. S. Simplifying Access to Targeted Protein Degraders via Nickel Electrocatalytic Cross-Coupling. Angew. Chem. 2024, 63, 16, e202319856.
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260. Zhang, H.-J.; Ociepa, M.; Nassir, M.; Zheng, B.; Lewicki, S. A.; Salmaso, V.; Baburi, H.; Nagel, J.; Mirza, S.; Bueschbell, B.; Al-Hroub, H.; Perzanowska, O.; Lin, Z.; Schmidt, M. A.; Eastgate, M. D.; Jacobson, K. A.; Muller, C. E.; Kowalska, J.; Jemielity, J.; Baran, P. S. Stereocontrolled Access to Thioisosteres of Nucleoside Di- and Triphosphates. Nature Chem. 2024, 16, 249–258.
2023
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259. Gao, Y.; Baran, P. S. Nickel-Catalyzed Enantioselective Decarboxylative Acylation: Rapid, Modular Access to α-Amino Ketones. Angew. Chem. 2023, 62, 50, e202315203.
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258. SSofiadis, M.; Xu, D.; Rodriguez, A. J.; Nissl, B.; Clementson, S.; Petersen, N. N.; Baran, P. S. Convergent Total Synthesis of (−)-Cyclopamine. J. Am. Chem. Soc. 2023, 145, 40, 21760–21765.
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257. Kawamata, Y.; Baran, P. S. Rapid Alternating Polarity as a Unique Tool for Synthetic Electrochemistry. J. Synth. Org. Chem. 2023, 81, 11, 1020–1027.
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256. Nassir, M.; Ociepa, M.; Zhang, H.-J.; Grant, L. N.; Simmons, B. J.; Oderinde, M. S.; Kawamata, Y.; Cauley, A. N.; Schmidt, M. A.; Eastgate, M. D.; Baran, P. S. Stereocontrolled Radical Thiophosphorylation. J. Am. Chem. Soc. 2023, 145, 28, 15088–15093.
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255. Garrido-Castro, A. F.; Hioki, Y.; Kusumoto, Y.; Hayashi, K.; Griffin, J.; Harper, K. C.; Kawamata, Y.; Baran, P. S. Scalable Electrochemical Decarboxylative Olefination Driven by Alternating Polarity. Angew. Chem. 2023, 62, 42, e202309157.
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254. Gao, Y.; Zhang, B.; He, J.; Baran, P. S. Ni-Electrocatalytic Enantioselective Doubly Decarboxylative C(sp3)–C(sp3) Cross Coupling. J. Am. Chem. Soc. 2023, 145, 21, 11518–11523.
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253. Zhang, B.; He, J,; Gao, Y.; Levy, L.; Oderinde, M. S.; Palkowitz, M. D.; Murali Dhar, T. G.; Collins, M. R.; Schmitt, D. C.; Bolduc, P. N.; Chen, T-Y.; Clementson, S.; Petersen, N. N.; Laudadio, G.; Bi, C.; Kawamata, Y.; Baran, P. S. Complex Molecule Synthesis by Electrocatalytic Decarboxylative Cross-Coupling. Nature 2023, 623, 745–751.
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252. Bi, C.; Wang, Y.; He, C.; Baran, P. S. Enantioselective Total Synthesis of (+)-KB343. J. Am. Chem. Soc. 2023, 145, 14, 7753–7757.
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251. Tang, J.; Li, W.; Chiu, T.-Y.; Martinez-Pena, F.; Chong, C. T.; Wei, Q.; Gazaniga, N.; West, T. J.; See, Y. Y.; Lairson, L. L.; Parker, C. G.; Baran, P. S. Synthesis of Portimines Reveals the Basis of Their Anti-Cancer Activity. Nature 2023, 622, 507–513.
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250. Hioki, Y.; Costantini, M.; Griffin, J.; Harper, K. C.; Merini, M. P.; Nissl, B.; Kawamata, Y.; Baran, P. S. Overcoming the Limitations of Kolbe Coupling with Waveform-Controlled Electrosynthesis. Science 2023, 380, 6640, 81–87.
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249. Kawamata, Y.; Ryu, K. A.; Hermann, G. N.; Sandahl, A.; Vantourout, J. C.; Olow, A. K.; Adams, L.-T. A.; Rivera-Chao, E.; Roberts, L. R.; Gnaim, S.; Nassir, M.; Oslund, R. C.; Fadeyi, O. O.; Baran, P. S. An Electroaffinity Labelling Platform for Chemoproteomic-Based Target Identification. Nature Chem. 2023, 15, 1267–1275.
2022
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248. Laudadio, G.; Palkowitz, M. D.; El-Hayek Ewing, T.; Baran, P. S. Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry. ACS Med. Chem. Lett. 2022, 13, 9, 1413–1420.
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247. Lou, S.-B. T.; Kawamata, Y.; Ewing, T.; Correa-Otero, G. A.; Collins, M. R.; Baran, P. S. Scalable, Chemoselective Nickel Electrocatalytic Sulfinylation of Aryl Halides with SO2. Angew. Chem. 2022, 61, 37, e202208080.
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246. Lin, Y.-C.; Schneider, F.; Eberle, K. J.; Chiodi, D.; Nakamura, H.; Reisberg, S. H.; Chen, J.; Saito, M.; Baran, P. S. Atroposelective Total Synthesis of Darobactin A. J. Am. Chem. Soc. 2022, 144, 32, 14458–14462.
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245. Palkowitz, M. D.; Laudadio, G.; Kolb, S.; Choi, J.; Oderinde, M. S.; El-Hayek Ewing, T.; Bolduc, P. N.; Chen, T.; Zhang, H.; Cheng, P. T. W.; Zhang, B.; Mandler, M. D.; Blasczak, V. D.; Richter, M. J.; Collins, M. R.; Schioldager, R. L.; Bravo, M.; Dhar, T. G. M.; Vokits, B.; Zhu, Y.; Echeverria, P.-G.; Poss, M. A.; Shaw, S. A.; Clementson, S.; Petersen, N. N.; Mykhailiuk, P. K.; Baran, P. S. Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis. J. Am. Chem. Soc. 2022, 144, 38, 17709–17720.
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244. Gao, Y.; Zhang, B.; Levy, L.; Zhang, H.-J.; He, C.; Baran, P. S. Ni-Catalyzed Enantioselective Dialkyl Carbinol Synthesis via Decarboxylative Cross-Coupling: Development, Scope, and Applications. J. Am. Chem. Soc. 2022, 144, 24, 10992–11002.
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243. Hayashi, K.; Griffin, J.; Harper, K. C.; Kawamata, Y.; Baran, P. S. Chemoselective (Hetero)Arene Electroreduction Enabled by Rapid Alternating Polarity. J. Am. Chem. Soc. 2022, 144, 13, 5762–5768.
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242. Zhang, B.; Gao, Y.; Hioki, Y.; Oderinde, M. S.; Qiao, J. X.; Rodriguez, K. X.; Zhang, H.-J.; Kawamata, Y.; Baran, P. S. Ni-Electrocatalytic Csp3–Csp3 Doubly Decarboxylative Coupling. Nature 2022, 606, 313–318.
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241. Gu, J.; Rodriquez, K. X.; Kanda, Y.; Yang, S.; Ociepa, M.; Wilke, H.; Abrishami, A. V.; Jørgensen, L.; Skak-Nielsen, T.; Chen, J. S.; Baran, P. S. Convergent Total Synthesis of (+)-Calcipotriol: A scalable, Modular Approach to Vitamin D Analogs. PNAS 2022, 119, e2200814119.
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240. Harwood, S. J.; Palkowitz, M. D.; Gannett, C. N.; Perez, P.; Yao, Z.; Sun, I.; Abruna, H. D.; Anderson, S. L.; Baran, P. S. Modular Terpene Synthesis Enabled by Mild Electrochemical Couplings. Science 2022, 375, 6582, 745–752.
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239. Gnaim, S.; Bauer, A.; Zhang, H.-J.; Chen, L.; Gannett, C.; Malapit, C. A.; Hill, D. E.; Vogt, D.; Tang, T.; Daley, R. A.; Hao, W.; Zeng, R.; Quertenmont, M.; Beck, W. D.; Kandahari, E.; Vantourout, J. C.; Echeverria, P.-G.; Abruna, H. D.; Blackmond, D. G.; Minteer, S. D.; Reisman, S. E.; Sigman, M. S.; Baran, P. S. Cobalt-Electrocatalytic HAT for Functionalization of Unsaturated C–C Bonds. Nature 2022, 605, 687–695.
2021
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238. Knouse, K. W.; Flood, D. T.; Vantourout, J. C.; Schmidt, M. A.; McDonald, I. M.; Eastgate, M. D.; Baran, P. S. Nature Chose Phosphates and Chemists Should Too: How Emerging P(V) Methods Can Augment Existing Strategies. ACS Cent. Sci. 2021, 7, 9, 1473–1485.
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237. Ociepa, M.; Knouse, K. W.; He, D.; Vantourout, J. C.; Flood, D. T.; Padial, N. M.; Chen, J. S.; Sanchez, B. B.; Sturgell, E. J.; Zheng, B.; Qiu, S.; Schmidt, M. A.; Eastgate, M. D.; Baran, P. S. Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent. Org. Lett. 2021, 23, 24, 9337–9342.
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236. Zhang, H.-J.; Chen, L.; Oderinde, M. S.; Edwards, J. T.; Kawamata, Y.; Baran, P. S. Chemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols. Angew. Chem. Int. Ed. 2021, 60, 20700–20705.
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235. Choi, J.; Laudadio, G.; Godineau, E.; Baran, P. S. Practical and Regioselective Synthesis of C-4-Alkylated Pyridines. J. Am. Chem. Soc. 2021, 143, 31, 11927–11933.
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234. Maity, P.; Anandamurthy, A. S.; Shekerappa, V.; Vaidyanathan, R.; Zheng, B.; Zhu, J.; Schmidt, M. A.; Fox, R. J.; Knouse, K. W.; Vantourout, J. C.; Baran, P. S.; Eastgate, M. D. Synthesis of a Phosphorous Sulfur Incorporating Reagent for the Enantioselective Synthesis of Thiophosphates. Org. Synth. 2021, 98, 97-116.
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233. Huang, Y.; Knouse, K. W.; Qiu, S.; Hao, W.; Padial, N. M.; Vantourout, J. C.; Zheng, B.; Mercer, S. E.; Lopez-Ogalla, J.; Narayan, R.; Olson, R. E.; Blackmond, D. G.; Eastgate, M. D.; Schmidt, M. A.; McDonald, I. M.; Baran, P. S. A P(V) Platform for Oligonucleotide Synthesis. Science 2021, 373, 1265–1270.
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232. Kawamata, Y.; Hayashi, K.; Carlson, E.; Shaji, S.; Waldmann, D.; Simmons, B. J.; Edwards, J. T.; Zapf, C. W.; Saito, M.; Baran, P. S. Chemoselective Electrosynthesis Using Rapid Alternating Polarity. J. Am. Chem. Soc. 2021, 143, 40, 16580–16588.
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231. Gao, Y.; Hill, D. E.; Hao, W.; McNicholas, B. J.; Vantourout, J. C.; Hadt, R. G.; Reisman, S. E.; Blackmond, D. G.; Baran, P. S. Electrochemical Nozaki–Hiyama–Kishi Coupling: Scope, Applications, and Mechanism. J. Am. Chem. Soc. 2021, 143, 25, 9478–9488.
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230. Barton, L. M.; Chen, L.; Blackmond, D. G.; Baran, P. S. Electrochemical Borylation of Carboxylic Acids. PNAS 2021, 118, e2109408118.
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229. Saito, M.; Kawamata, Y.; Meanwell, M.; Navratil, R.; Chiodi, D.; Carlson, E.; Hu, P.; Chen, L.; Udyavara, S.; Kingston, C.; Tanwar, M.; Tyagi, S.; McKillican, B. P.; Gichinga, M. G.; Schmidt, M. A.; Eastgate, M. D.; Lamberto, M. He, C.; Tang, T.; Malapit, C. A.; Sigman, M. S.; Minteer, S. D.; Neurock, M.; Baran, P. S. N-Ammonium Ylide Mediators for Electrochemical C–H Oxidation. J. Am. Chem. Soc. 2021, 143, 20, 7859–7867.
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228. Peters, D. S.; Pitts, C. R.; McClymont, K. S.; Stratton, T. P.; Bi, C.; Baran, P. S. Ideality in Context: Motivations for Total Synthesis. Acc. Chem. Res. 2021, 54, 3, 605–617.
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227. Gnaim, S.; Vantourout, J. C.; Serpier, F.; Echeverria, P.-G.; Baran, P. S. Carbonyl Desaturation: Where Does Catalysis Stand?. ACS Catal. 2021, 11, 2, 883–892.
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226. Zhao, J.-X.; Chang, Y.-X.; He, C.; Burke, B. J.; Collins, M. R.; Del Bel, M.; Elleraas, J. Gallego, G. M.; Montgomery, T. P.; Mousseau, J. J.; Nair, S. K.; Perry, M. A.; Spangler, J. E.; Vantourout, J. C.; Baran, P. S. 1,2-Difunctionalized Bicyclo[1.1.1]pentanes: Long–Sought-After Mimetics for Ortho/Meta-Substituted Arenes. PNAS 2021, 118, e2108881118.
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225. Chen, L.; Barton, L. M.; Vantourout, J. C.; Xu, Y.; Chu, C.; Johnson, E. C.; Sabatini, J. J.; Baran, P. S. Electrochemical Cyclobutane Synthesis in Flow: Scale-Up of a Promising Melt-Castable Energetic Intermediate. Org. Process Res. Dev. 2021, 25, 12, 2639–2645.
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224. Gnaim, S.; Takahira, Y.; Wilke, H. R.; Yao, Z.; Li, J.; Delbrayelle, D.; Echeverria, P.-G.; Vantourout, J. C.; Baran, P. S. Electrochemically Driven Desaturation of Carbonyl Compounds. Nature Chem. 2021, 13, 367–372.
2020
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223. Hu, P.; Peters, B. K.; Malapit, C. A.; Vantourout, J. C.; Wang, P.; Li, J.; Mele, L.; Echeverria, P.-G.; Minteer, S. D.; Baran, P. S. Electroreductive Olefin–Ketone Coupling. J. Am. Chem. Soc. 2020, 142, 50, 20979–20986.
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222. Vantourout, J. C.; Adusumalli, S. R.; Knouse, K. W.; Flood, D. T.; Ramirez, A.; Padial, N. M.; Istrate, A.; Maziarz, K.; deGruyter, J. N.; Merchant, R. R.; Qiao, J. X.; Schmidt, M. A.; Deery, M. J.; Eastgate, M. D.; Dawson, P. E.; Bernardes, G. J. L.; Baran, P. S. Serine-Selective Bioconjugation. J. Am. Chem. Soc. 2020, 142, 41, 17236–17242.
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221. Sheng, T.; Zhang, H.-J.; Shang, M.; He, C.; Vantourout, J. C.; Baran, P. S. Electrochemical Decarboxylative N-Alkylation of Heterocycles. Org. Lett. 2020, 22, 19, 7594–7598.
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219. Kanda, Y.; Ishihara, Y.; Wilde, N. C.; Baran, P. S. Two-Phase Total Synthesis of Taxanes: Tactics and Strategies. J. Org. Chem. 2020, 85, 16, 10293–10320.
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217. Flood, D. T.; Knouse, K. W.; Vantourout, J. C.; Kitamura, S.; Sanchez, B. B.; Sturgell, E. J.; Chen, J. S.; Wolan, D. W.; Baran, P. S.; Dawson, P. E. Synthetic Elaboration of Native DNA by RASS (SENDR). ACS Cent. Sci. 2020, 6, 10, 1789–1799.
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216. Kanda, Y.; Nakamura, H.; Umemiya, S.; Puthukanoori, R. K.; Appala, V. R. M.; Gaddamanugu, G. K.; Paraselli, B. R.; Baran, P. S. Two-Phase Synthesis of Taxol. J. Am. Chem. Soc. 2020, 142, 23, 10526–10533.
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215. Kawamata, Y.; Baran, P. S. Electrosynthesis: Sustainability Is Not Enough. Joule 2020, 4, 701–704.
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214. Flood, D. T.; Kingston, C.; Vantourout, J. C.; Dawson, P. E.; Baran, P. S. DNA Encoded Libraries: A Visitor's Guide. Isr. J. Chem. 2020, 60, 268–280.
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213. Xu, D.; Rivas-Bascón, N.; Padial, N. M.; Knouse, K. W.; Zheng, B.; Vantourout, J. C.; Schmidt, M. A.; Eastgate, M. D.; Baran, P. S. Enantiodivergent Formation of C–P Bonds: Synthesis of P-Chiral Phosphines and Methylphosphonate Oligonucleotides. J. Am. Chem. Soc. 2020, 142, 12, 5785–5792.
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212. Flood, D. T.; Zhang, X.; Fu, X.; Zhao, Z.; Asai, S.; Sanchez, B. B.; Sturgell, E. J.; Vantourout, J. C.; Richardson, P.; Flanagan, M. E.; Piotrowski, D. W.; Kölmel, D. K.; Wan, J.; Tsai, M.-H.; Chen, J. S.; Baran, P. S.; Dawson, P. E. RASS-Enabled S/P−C and S−N Bond Formation for DEL Synthesis. Angew. Chem. Int. Ed. 2020, 59, 7377–7383.
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210. Kingston, C.; Palkowitz, M. D.; Takahira, Y.; Vantourout, J. C.; Peters, B. K.; Kawamata, Y.; Baran, P. S. A Survival Guide for the “Electro-curious”. Acc. Chem. Res. 2020, 53, 1, 72–83.
2019
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209. Barton, L. M.; Edwards, J. T.; Johnson, E. C.; Bukowski, E. J.; Sausa, R. C.; Byrd, E. F. C.; Orlicki, J. A.; Sabatini, J. J.; Baran, P. S. Impact of Stereo- and Regiochemistry on Energetic Materials. J. Am. Chem. Soc. 2019, 141, 32, 12531–12535.
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208. Xiang, J.; Shang, M.; Kawamata, Y.; Lundberg, H.; Reisberg, S. H.; Chen, M.; Mykhailiuk, P.; Beutner, G.; Collins, M. R.; Davies, A.; Del Bel, M.; Gallego, G. M.; Spangler, J. E.; Starr, J.; Yang, S.; Blackmond, D. G.; Baran, P. S. Hindered Dialkyl Ether Synthesis with Electrogenerated Carbocations. Nature 2019, 573, 398–402.
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207. Flood, D. T.; Asai, S.; Zhang, X.; Wang, J.; Yoon, L.; Adams, Z. C.; Dillingham, B. C.; Sanchez, B. B.; Vantourout, J. C.; Flanagan, M. E.; Piotrowski, D. W.; Richardson, P.; Green, S. A.; Shenvi, R. A.; Chen, J. S.; Baran, P. S.; Dawson, P. E. Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support. J. Am. Chem. Soc. 2019, 141, 25, 9998–10006.
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206. Ni, S.; Padial, N. M.; Kingston, C.; Vantourout, J. C.; Schmitt, D. C.; Edwards, J. T.; Kruszyk, M. M.; Merchant, R. R.; Mykhailiuk, P. K.; Sanchez, B. B.; Yang, S.; Perry, M. A.; Gallego, G. M.; Mousseau, J. J.; Collins, M. R.; Cherney, R. J.; Lebed, P. S.; Chen, J. S.; Qin, T.; Baran, P. S. A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines. J. Am. Chem. Soc. 2019, 141, 16, 6726–6739.
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205. Takahira, Y.; Chen, M.; Kawamata, Y.; Mykhailiuk, P.; Nakamura, H.; Peters, B. K.; Reisburg, S. H.; Li, C.; Chen, L.; Hoshikawa, T.; Shibuguchi, T.; Baran, P. S. Electrochemical C(sp3)–H Fluorination. Synlett 2019, 30, 1178–1192.
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204. Kawamata, Y.; Vantourout, J. C.; Hickey, D. P.; Bai, P.; Chen, L.; Hou, Q.; Qiao, W.; Barman, K.; Edwards, M. A.; Garrido-Castro, A. F.; deGruyter, J. N.; Nakamura, H.; Knouse, K.; Qin, C.; Clay, K. J.; Bao, D.; Li, C.; Starr, J. T.; Garcia-Irizarry, C.; Sach, N.; White, H. S.; Neurock, M.; Minteer, S. D.; Baran, P. S. Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications. J. Am. Chem. Soc. 2019, 141, 15, 6392–6402.
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203. Peters, B. K.; Rodriguez, K. X.; Reisberg, S. H.; Beil, S. B.; Hickey, D. P.; Kawamata, Y.; Collins, M.; Starr, J.; Chen, L.; Udyavara, S.; Klunder, K.; Gorey, T. J.; Anderson, S. L.; Neurock, M.; Minteer, S. D.; Baran, P. S. Scalable and Safe Synthetic Organic Electroreduction Inspired by Li-ion Battery Chemistry. Science 2019, 363, 838–845.
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202. Shang, M.; Feu, K. S.; Vantourout, J. C.; Barton, L. M.; Osswald, H. L.; Kato, N.; Gagaring, K.; McNamara, C. W.; Chen, G.; Hu, L.; Ni, S.; Fernández-Canelas, P.; Chen, M.; Merchant, R. R.; Qin, T.; Schreiber, S. L.; Melillo, B.; Yu, J.-Q.; Baran, P. S. Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids. PNAS 2019, 116, 8721–8727.
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200. Chen, T.-G.; Zhang, H.; Mykhailiuk, P. K.; Merchant, R. R.; Smith, C. A.; Qin, T.; Baran, P. S. Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents. Angew. Chem. Int. Ed. 2019, 58, 8, 2454–2458.
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198. Kingston, C.; Wallace, M. A.; Allentoff, A. J.; deGruyter, J. N.; Chen, J. S.; Gong, S. X.; Bonacorsi, S.; Baran, P. S. Direct Carbon Isotope Exchange through Decarboxylative Carboxylation. J. Am. Chem. Soc. 2019, 141, 2, 774–779.
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197. Smith, J. M.; Dixon, J. A.; deGruyter, J. N.; Baran, P. S. Alkyl Sulfinates: Radical Precursors Enabling Drug Discovery. J. Med. Chem. 2019, 62, 5, 2256–2264.
2018
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196. Ni, S.; Garrido-Castro, A. F.; Merchant, R. R.; deGruyter, J. N.; Schmitt, D. C.; Mousseau, J. J.; Gallego, G. M.; Yang, S.; Collins, M. R.; Qiao, J. X.; Yeung, K.-S.; Langley, D. R.; Poss, M. A.; Scola, P. M.; Qin, T.; Baran, P. S. A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling. Angew Chem. Int. Ed. 2018, 57, 44, 14560–14565.
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195. Wang, J.; Shang, M.; Lundberg, H.; Feu, K. S.; Hecker, S. J.; Qin, T.; Blackmond, D. G.; Baran, P. S. Cu-Catalyzed Decarboxylative Borylation. ACS Catal. 2018, 8, 10, 9537–9542.
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194. Knouse, K. W.; deGruyter, J. N.; Schmidt, M. A.; Zheng, B.; Vantourout, J. C.; Kingston, C.; Mercer, S. E.; McDonald, I. M.; Olson, R. E.; Zhu, E.; Hang, C.; Zhu, J.; Yuan, C.; Wang, Q.; Park, P.; Eastgate, M. D.; Baran, P. S. Unlocking P(V): Reagents for Chiral Phosphorothioate Synthesis. Science 2018, 361, 6408, 1234–1238.
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193. Smith, J. M.; Harwood, S. J.; Baran, P. S. Radical Retrosynthesis. Acc. Chem. Res. 2018, 51, 8, 1807–1817.
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192. Chen, T.-G.; Barton, L. M.; Lin, Y.; Tsien, J.; Kossler, D.; Bastida, I.; Asai, S.; Bi, C.; Chen, J. S.; Shan, M.; Fang, H.; Fang, F. G.; Choi, H.; Hawkins, L.; Qin, T.; Baran, P. S. Building C(sp3)-Rich Complexity by Combining Cycloaddition and C–C Cross-Coupling Reactions. Nature 2018, 560, 350–354.
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190. Wang, J.; Lundberg, H.; Asai, S.; Martin-Acosta, P.; Chen, J. S.; Brown, S.; Farrell, W.; Dushin, R. G.; O'Donnell, C. J.; Ratnayake, A. S.; Richardson, P.; Liu, Z.; Qin, T.; Blackmond, D. G.; Baran, P. S. Kinetically Guided Radical-Based Synthesis of C(sp3)−C(sp3) Linkages on DNA. PNAS 2018, 115, E6404–E6410.
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189. Baran, P. S. Natural Product Total Synthesis: As Exciting as Ever and Here To Stay. J. Am. Chem. Soc. 2018, 140, 14, 4751–4755.
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188. Chu, H.; Dünstl, G.; Felding, J.; Baran, P. S. Divergent Synthesis of Thapsigargin Analogs. Bioorg. Med. Chem. Lett. 2018, 28, 16, 2705–2707.
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186. Merchant, R. R.; Edwards, J. T.; Qin, T.; Kruszyk, M. M.; Bi, C.; Che, G.; Bao, D.-H.; Qiao, W.; Sun, L.; Collins, M. R.; Fadeyi, O. O.; Gallego, G. M.; Mousseau, J. J.; Nuhant, P.; Baran, P. S. Modular Radical Cross-Coupling with Sulfones Enables Access to sp3-rich (Fluoro)Alkylated Scaffolds. Science 2018, 360, 6384, 75–80.
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185. Yan, M.; Kawamata, Y.; Baran, P. S. Synthetic Organic Electrochemistry: Calling All Engineers. Angew. Chem. Int. Ed. 2018, 57, 4149–4155.
2017
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184. Parker, C. G.; Kuttruff, C. A.; Galmozzi, A.; Jørgensen, L.; Yeh, C.-H.; Hermanson, D. J.; Wang, Y.; Artola, M.; McKerrall, S. J.; Josyln, C. M.; Nørremark, B.; Dünstl, G.; Felding, J.; Saez, E.; Baran, P. S.; Cravatt, B. F. Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs. ACS Cent. Sci. 2017, 3, 12, 1276–1285.
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183. deGruyter, J. N.; Malins, L. R.; Wimmer, L.; Clay, K. J.; Lopez-Ogalla, J.; Qin, T.; Cornella, J.; Liu, Z.; Che, G.; Bao, D.; Stevens, J. M.; Xiao, J. X.; Allen, M. P.; Poss, M. A.; Baran, P. S. CITU: A Peptide and Decarboxylative Coupling Reagent. Org. Lett. 2017, 19, 22, 6196–6199.
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182. Yan, M.; Kawamata, Y.; Baran, P. S. Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance. Chem. Rev. 2017, 117, 21, 13230–13319.
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180. Trammell, R.; See, Y. Y.; Herrmann, A. T.; Xie, N.; Diaz, D. E.; Siegler, M. A.; Baran, P. S.; Garcia-Bosch, I. Decoding the Mechanism of Intramolecular Cu-Directed Hydroxylation of sp3 C–H Bonds. J. Org. Chem. 2017, 82, 15, 7887–7904.
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179. deGruyter, J. N.; Malins, L. R.; Baran, P. S. Residue-Specific Peptide Modification: A Chemist’s Guide. Biochemistry 2017, 56, 30, 3863–3873.
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173. Sandfort, F.; O'Neill, M. J.; Cornella, J.; Wimmer, L.; Baran, P. S. Alkyl−(Hetero)Aryl Bond Formation via Decarboxylative Cross-Coupling: A Systematic Analysis. Angew. Chem. Int. Ed. 2017, 56, 3319–3323.
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172. Lopchuk, J. M.; Fjelbye, K.; Kawamata, Y.; Malins, L. R.; Pan, C.-M.; Gianatassio, R.; Wang, J.; Prieto, L.; Bradow, J.; Brandt, T. A.; Collins, M. R.; Elleraas, J.; Ewanicki, J.; Farrell, W.; Fadeyi, O. O.; Gallego, G. M.; Mousseau, J. J.; Oliver, R.; Sach, N. W.; Smith, J. K.; Spangler, J. E.; Zhu, H.; Zhu, J.; Baran, P. S. Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity. J. Am. Chem. Soc. 2017, 139, 8, 3209–3226.
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171. Lo, J. C.; Kim, D.; Pan, C.-M.; Edwards, J. T.; Yabe, Y.; Gui, J.; Qin, T.; Gutierrez, S.; Giacoboni, J.; Smith, M. W.; Holland, P. L.; Baran, P. S. Fe-Catalyzed C–C Bond Construction from Olefins via Radicals. J. Am. Chem. Soc. 2017, 139, 6, 2484–2503.
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169. Qin, T.; Malins, L. R.; Edwards, J. T.; Merchant, R. R.; Novak, A. J. E.; Zhong, J. Z.; Mills, R. B.; Yan, M.; Yuan, C.; Eastgate, M. D.; Baran, P. S. Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms. Angew. Chem. Int. Ed. 2017, 56, 260–265.
2016
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167. Yan, M.; Lo, J. C.; Edwards, J. T.; Baran, P. S. Radicals: Reactive Intermediates with Translational Potential. J. Am. Chem. Soc. 2016, 138, 39, 12692–12714.
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164. Wang, J.; Qin, T,; Chen, T-G.; Wimmer, L.; Edwards, J. T.; Cornella, J.; Vokits, B.; Shaw, S. A.; Baran, P. S. Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids. Angew. Chem. Int. Ed. 2016, 55, 9676–9679.
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161. Horn, E. J.; Rosen, B. R.; Baran, P. S. Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method. ACS Cent. Sci. 2016, 2, 5, 302–308.
2015
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153. Jin, Y.; Yeh, C.-H.; Kuttruff, C. A.; Jørgensen, L.; Dunstl, G.; Felding, J.; Natarajan, S. R.; Baran, P. S. C–H Oxidation of Ingenanes Enables Potent and Selective Protein Kinase C Isoform Activation. Angew. Chem. Int. Ed. 2015, 54, 14044–14048.
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149. Michaudel, Q.; Ishihara, Y.; Baran, P. S. Academia–Industry Symbiosis in Organic Chemistry. Acc. Chem. Res. 2015, 48, 3, 712–721.
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148. Renata, H.; Zhou, Q.; Dünstl, G.; Felding, J.; Merchant, R. R.; Yeh, C.-H.; Baran, P. S. Development of a Concise Synthesis of Ouabagenin and Hydroxylated Corticosteroid Analogues. J. Am. Chem. Soc. 2015, 137, 3, 1330–1340.
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147. Maimone, T. J.; Ishihara, Y.; Baran, P. S. Scalable Total Syntheses of (−)-Hapalindole U and (+)-Ambiguine H. Tetrahedron 2015, 71, 3652–3665.
2014
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144. Rodriguez, R. A.; Steed, D. B.; Kawamata, Y.; Su, S.; Smith, P. A.; Steed, T. C.; Romesberg, F. E.; Baran, P. S. Axinellamines as Broad-Spectrum Antibacterial Agents: Scalable Synthesis and Biology. J. Am. Chem. Soc. 2014, 136, 43, 15403–15413.
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143. Michaudel, Q.; Journot, G.; Regueiro-Ren, A.; Goswami, A.; Guo, Z.; Tully, T. P.; Zou, L.; Ramabhadran, R.; Houk, K. N.; Baran, P. S. Improving Physical Properties via C-H Oxidation: Chemical and Enzymatic Approaches. Angew. Chem. Int. Ed. 2014, 53, 12091–12096.
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142. O'Brien, A. G.; Maruyama, A.; Inokuma, Y.; Fujita, M.; Baran, P. S.; Blackmond, D. G. Radical C-H Functionalization of Heteroarenes under Electrochemical Control. Angew. Chem. Int. Ed. 2014, 53, 11868–11871.
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137. McKerrall, S. J.; Jørgensen, L.; Kuttruff, C. A.; Ungeheuer, F.; Baran, P. S. Development of a Concise Synthesis of (+)-Ingenol. J. Am. Chem. Soc. 2014, 136, 15, 5799–5810.
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133. Gutekunst, W.; Baran, P. S. Applications of C–H Functionalization Logic to Cyclobutane Synthesis. J. Org. Chem. 2014, 79, 6, 2430–2452.
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130. Kuttruff, C. A.; Eastgate, M. D.; Baran, P. S. Natural Product Synthesis in the Age of Scalability. Nat. Prod. Rep. 2014, 31, 419–432.
2013
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129. Teufel, R.; Miyanaga, A.; Michaudel, Q.; Stull, F.; Louie, G.; Noel, J. P.; Baran, P. S.; Palfey, B.; Moore, B. S. Flavin-mediated Dual Oxidation Controls an Enzymatic Favorskii-type Rearrangement. Nature 2013, 503, 552–556.
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128. Zhou, Q.; Gui, J.; Pan, C.-M.; Albone, E.; Cheng, X.; Suh, E. M.; Grasso, L.; Ishihara, Y.; Baran, P. S. Bioconjugation by Native Chemical Tagging of C–H Bonds. J. Am. Chem. Soc. 2013, 135, 35, 12994–12997.
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126. O'Hara, F.; Blackmond, D. G.; Baran, P. S. Radical-Based Regioselective C–H Functionalization of Electron-Deficient Heteroarenes: Scope, Tunability, and Predictability. J. Am. Chem. Soc. 2013, 135, 32, 12122–12134.
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125. Cherney, E. C.; Green, J. C.; Baran, P. S. Synthesis of ent-Kaurane and Beyerane Diterpenoids by Controlled Fragmentations of Overbred Intermediates. Angew. Chem. Int. Ed. 2013, 52, 9019–9022.
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124. Rosen, B. R.; Simke, L. R.; Thuy-Boun, P. S.; Dixon, D. D.; Yu, J.-Q.; Baran, P. S. C–H Functionalization Logic Enables Synthesis of (+)-Hongoquercin A and Related Compounds. Angew. Chem. Int. Ed. 2013, 52, 7317–7320.
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123. O'Hara, F.; Baxter, R. D.; O'Brien, A. G.; Collins, M. R.; Dixon, J. A.; Fujiwara, Y.; Ishihara, Y.; Baran, P. S. Preparation and Purification of Zinc Sulfinate Reagents for Drug Discovery. Nature Protocols 2013, 8, 1042–1047.
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122. Ishihara, Y.; Mendoza, A.; Baran, P. S. Total Synthesis of Taxane Terpenes: Cyclase Phase. Tetrahedron 2013, 69, 5685–5701.
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121. Usui, I.; Lin, D. W.; Masuda, T.; Baran, P. S. Convergent Synthesis and Structural Confirmation of Phellodonin and Sarcodonin ε. Org. Lett. 2013, 15, 9, 2080–2083.
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120. Zhou, Q.; Ruffoni, A.; Gianatassio, R.; Fujiwara, Y.; Sella, E.; Shabat, D.; Baran, P. S. Direct Synthesis of Fluorinated Heteroarylether Bioisosteres. Angew. Chem. Int. Ed. 2013, 52, 3949–3952.
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119. Wengryniuk, S. E.; Weickgenannt, A.; Reiher, C.; Strotman, N. A.; Chen, K.; Eastgate, M. D.; Baran, P. S. Regioselective Bromination of Fused Heterocyclic N-Oxides. Org. Lett. 2013, 15, 4, 792–795.
2012
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117. Keasling, J. D.; Mendoza, A.; Baran, P. S. Synthesis: A Constructive Debate. Nature 2012, 492, 188–189.
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116. Fujiwara, Y.; Dixon, J. A.; O'Hara, F.; Funder, E. D.; Dixon, D. D.; Rodriguez, R. A.; Baxter, R. D.; Herle, B.; Sach, N.; Collins, M. R.; Ishihara, Y.; Baran, P. S. Practical and Innate Carbon–Hydrogen Functionalization of Heterocycles. Nature 2012, 492, 95–100.
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115. Foo, K.; Usui, I.; Götz, D. C. G.; Werner, E. W.; Holte, D.; Baran, P. S. Scalable, Enantioselective Synthesis of Germacrenes and Related Sesquiterpenes Inspired by Terpene Cyclase Phase Logic. Angew. Chem. Int. Ed. 2012, 51, 11491–11495.
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114. Voica, A.-F.; Mendoza, A.; Gutekunst, W. R.; Fraga, J. O.; Baran, P. S. Guided Desaturation of Unactivated Aliphatics. Nature Chem. 2012, 4, 629–635.
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113. Gutekunst, W. R.; Gianatassio, R.; Baran, P. S. Sequential Csp3-H Arylation and Olefination: Total Synthesis of the Proposed Structure of Pipercyclobutanamide A. Angew. Chem. Int. Ed. 2012, 51, 7507–7510.
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112. Dixon, D. D.; Lockner, J. W.; Zhou, Q.; Baran, P. S. Scalable, Divergent Synthesis of Meroterpenoids via “Borono-sclareolide”. J. Am. Chem. Soc. 2012, 134, 20, 8432–8435.
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111. Michaudel, Q.; Thevenet, D.; Baran, P. S. Intermolecular Ritter-Type C–H Amination of Unactivated sp3 Carbons. J. Am. Chem. Soc. 2012, 134, 5, 2547–2550.
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110. Fujiwara, Y.; Dixon, J. A.; Rodriguez, R. A.; Baxter, R. D.; Dixon, D. D.; Collins, M. R.; Blackmond, D. G.; Baran, P. S. A New Reagent for Direct Difluoromethylation. J. Am. Chem. Soc. 2012, 134, 3, 1494–1497.
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109. Holte, D.; Gotz, D. C. G.; Baran, P. S. An Approach to Mimicking the Sesquiterpene Cyclase Phase by Nickel-Promoted Diene/Alkyne Cooligomerization. J. Org. Chem. 2012, 77, 2, 825–842.
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108. Mendoza, A.; Ishihara, Y.; Baran, P. S. Scalable Enantioselective Total Synthesis of Taxanes. Nature Chem. 2012, 4, 21–25.
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107. Brückl, T.; Baxter, R. D.; Ishihara, Y.; Baran, P. S. Innate and Guided C–H Functionalization Logic. Acc. Chem. Res. 2012, 45, 6, 826–839.
2011
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106. Gutekunst, W. R.; Baran, P. S. Total Synthesis and Structural Revision of the Piperarborenines via Sequential Cyclobutane C–H Arylation. J. Am. Chem. Soc. 2011, 133, 47, 19076–19079.
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105. Lockner, J. W.; Dixon, D. D.; Risgaard, R.; Baran, P. S. Practical Radical Cyclizations with Arylboronic Acids and Trifluoroborates. Org. Lett. 2011, 13, 20, 5628–5631.
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104. Seiple, I. B.; Su, S.; Nakamura, A.; Yamaguchi, J.; Jørgensen, L.; Rodriguez, R. A.; O'Malley, D. P.; Gaich, T.; Köck, M.; Baran, P. S. Enantioselective Total Syntheses of (−)-Palau’amine, (−)-Axinellamines, and (−)-Massadines. J. Am. Chem. Soc. 2011, 133, 37, 14710–14726.
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103. Su, S.; Rodriguez, R. A.; Baran, P. S. Scalable, Stereocontrolled Total Syntheses of (±)-Axinellamines A and B. J. Am. Chem. Soc. 2011, 133, 35, 13922–13925.
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102. Ji, Y.; Brueckl, T.; Fujiwara, Y.; Seiple, I. B.; Su, S.; Blackmond, D. G.; Baran, P. S. Innate C-H Trifluoromethylation of Heterocycles. PNAS 2011, 108, 35, 14411–14415.
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101. Shi, J.; Manolikakes, G.; Yeh, C.-Y.; Guerrero, C. A.; Shenvi, R. A.; Shigehisa, H.; Baran, P. S. Scalable Synthesis of Cortistatin A and Related Structures. J. Am. Chem. Soc. 2011, 133, 20, 8014–8027.
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100. Fujiwara, Y.; Domingo, V.; Seiple, I. B.; Gianatassio, R.; Del Bel, M.; Baran, P. S. Practical C−H Functionalization of Quinones with Boronic Acids. J. Am. Chem. Soc. 2011, 133, 10, 3292–3295.
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99. Newhouse, T.; Baran, P. S. If C–H Bonds Could Talk: Selective C-H Bond Oxidation. Angew. Chem. Int. Ed. 2011, 50, 3362–3374.
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98. Foo, K.; Newhouse, T.; Mori, I.; Takayama, H.; Baran, P. S. Total Synthesis Guided Structure Elucidation of (+)-Psychotetramine. Angew. Chem. Int. Ed. 2011, 50, 12, 2716–2719.
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97. Cherney, E. C.; Baran, P. S. Terpenoid-Alkaloids: Their Biosynthetic Twist of Fate and Total Synthesis. Isr. J. Chem. 2011, 51, 391–405.
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96. Gutekunst, W. R.; Baran, P. S. C–H Functionalization Logic in Total Synthesis. Chem. Soc. Rev. 2011, 40, 1976–1991.
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95. Jessing, M.; Baran, P. S. Oxidative Coupling of Indoles with 3-Oxindoles. Heterocycles 2011, 82, 2, 1739–1745.
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94. Lin, D. W.; Masuda, T.; Biskup, M. B.; Nelson, J. D.; Baran, P. S. Synthesis-Guided Structure Revision of the Sarcodonin, Sarcoviolin, and Hydnellin Natural Product Family. J. Org. Chem. 2011, 76, 4, 1013–1030.
2010
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93. Seiple, I. B.; Rodriguez, R. A.; Gianatassio, R.; Fujiwara, Y.; Sobel, A. L.; Baran, P. S. Direct C−H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids. J. Am. Chem. Soc. 2010, 132, 38, 13194–13196.
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92. Ishihara, Y.; Baran, P. S. Two-Phase Terpene Total Synthesis: Historical Perspective and Application to the Taxol® Problem. Synlett 2010, 12, 1733–1745.
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91. Gaich, T.; Baran, P. S. Aiming for the Ideal Synthesis. J. Org. Chem. 2010, 75, 14, 4657–4673.
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90. Newhouse, T.; Lewis, C. A.; Eastman, K. J.; Baran, P. S. Scalable Total Syntheses of N-Linked Tryptamine Dimers by Direct Indole−Aniline Coupling: Psychotrimine and Kapakahines B and F. J. Am. Chem. Soc. 2010, 132, 20, 7119–7137.
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89. Chen, K.; Ishihara, Y.; Galán, M. M.; Baran, P. S. Total Synthesis of Eudesmane Terpenes: Cyclase Phase. Tetrahedron 2010, 66, 4738–4744.
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88. Seiple, I. B.; Su, S.; Young, I. S.; Lewis, C. A.; Yamaguchi, J.; Baran, P. S. Total Synthesis of Palau’amine. Angew. Chem. Int. Ed. 2010, 49, 1095–1098.
2009
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87. Chen, K.; Eschenmoser, A.; Baran, P. S. Strain Release in C–H Bond Activation?. Angew. Chem. Int. Ed. 2009, 48, 9705–9708.
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86. Maimone, T. J.; Shi, J.; Ashida, S.; Baran, P. S. Total Synthesis of Vinigrol. J. Am. Chem. Soc. 2009, 131, 47, 17066–17067.
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85. Krawczuk, P. J.; Schöne, N.; Baran, P. S. A Synthesis of the Carbon Skeleton of Maoecrystal V. Org. Lett. 2009, 11, 21, 4774–4776.
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84. Luzung, M. R.; Lewis, C. A.; Baran, P. S. Direct, Chemoselective N-tert-Prenylation of Indoles by C–H Functionalization. Angew. Chem. Int. Ed. 2009, 48, 7025–7029.
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83. Newhouse, T.; Baran, P. S.; Hoffmann, R. W. The Economies of Synthesis. Chem. Soc. Rev. 2009, 38, 3010–3021.
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82. Burns, N. Z.; Krylova, I. N.; Hannoush, R. N.; Baran, P. S. Scalable Total Synthesis and Biological Evaluation of Haouamine A and Its Atropisomer. J. Am. Chem. Soc. 2009, 131, 26, 9172–9173.
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81. Chen, K.; Baran, P. S. Total Synthesis of Eudesmane Terpenes by Site-Selective C–H Oxidations. Nature 2009, 459, 824–828.
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80. Young, I. S.; Baran, P. S. Protecting-Group-Free Synthesis as an Opportunity for Invention. Nature Chem. 2009, 1, 193–205.
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79. Shi, J.; Shigehisa, H.; Guerrero, C. A.; Shenvi, R. A.; Li, C.-C.; Baran, P. S. Stereodivergent Synthesis of 17-α and 17-β-Aryl Steroids: Application and Biological Evaluation of D-Ring Cortistatin Analogues. Angew. Chem. Int. Ed. 2009, 48, 4328–4331.
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78. Newhouse, T.; Lewis, C. A.; Baran, P. S. Enantiospecific Total Syntheses of Kapakahines B and F. J. Am. Chem. Soc. 2009, 131, 18, 6360–6361.
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77. Burns, N. Z.; Baran, P. S.; Hoffmann, R. W. Redox Economy in Organic Synthesis. Angew. Chem. Int. Ed. 2009, 48, 2854–2867.
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76. Shenvi, R. A.; O'Malley, D. P.; Baran, P. S. Chemoselectivity: The Mother of Invention in Total Synthesis. Acc. Chem. Res. 2009, 42, 4, 530–541.
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75. Burns, N. Z.; Jessing, M.; Baran, P. S. Total Synthesis of Haouamine A: the Indeno-tetrahydropyridine Core. Tetrahedron 2009, 65, 6600–6610.
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74. Hafensteiner, B. D.; Escribano, M.; Petricci, E.; Baran, P. S. An Improved Synthesis of α,β-Unsaturated Nitrones Relevant to the Stephacidins and Analogs Thereof. Bioorg. Med. Chem. Lett. 2009, 19, 3808–3810.
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73. Eastman, K.; Baran, P. S. A Simple Method for the Direct Arylation of Indoles. Tetrahedron 2009, 65, 3149–3154.
2008
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72. Richter, J. M.; Ishihara, Y.; Masuda, T.; Whitefield, B. W.; Llamas, T.; Pohjakallio, A.; Baran, P. S. Enantiospecific Total Synthesis of the Hapalindoles, Fischerindoles, and Welwitindolinones via a Redox Economic Approach. J. Am. Chem. Soc. 2008, 130, 52, 17938–17954.
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71. Su, S.; Seiple, I. B.; Young, I. S.; Baran, P. S. Total Syntheses of (±)-Massadine and Massadine Chloride. J. Am. Chem. Soc. 2008, 130, 49, 16490–16491.
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70. DeMartino, M. P.; Chen, K.; Baran, P. S. Intermolecular Enolate Heterocoupling: Scope, Mechanism, and Application. J. Am. Chem. Soc. 2008, 130, 34, 11546–11560.
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69. Newhouse, T.; Baran, P. S. Total Synthesis of (±)-Psychotrimine. J. Am. Chem. Soc. 2008, 130, 33, 10886–10887.
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68. Chen, K.; Richter, J. M.; Baran, P. S. 1,3-Diol Synthesis via Controlled, Radical-Mediated C–H Functionalization. J. Am. Chem. Soc. 2008, 130, 23, 7247–7249.
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67. Shenvi, R. A.; Guerrero, C. A.; Shi, J.; Li, C.-C.; Baran, P. S. Synthesis of (+)-Cortistatin A. J. Am. Chem. Soc. 2008, 130, 23, 7241–7243.
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66. O'Malley, D. P.; Yamaguchi, J.; Young, I. S.; Seiple. I. B.; Baran, P. S. Total Synthesis of (±)-Axinellamines A and B. Angew. Chem. Int. Ed. 2008, 47, 3581–3583.
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65. Yamaguchi, J.; Seiple, I. B.; Young, I. S.; O'Malley, D. P.; Maue, M.; Baran, P. S. Synthesis of 1,9-Dideoxy-pre-axinellamine. Angew. Chem. Int. Ed. 2008, 47, 3578–3580.
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64. Maimone, T. J.; Voica, A.-F.; Baran, P. S. A Concise Approach to Vinigrol. Angew. Chem. Int. Ed. 2008, 47, 3054–3056.
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63. Burns, N. Z.; Baran, P. S. On the Origin of the Haouamine Alkaloids. Angew. Chem. Int. Ed. 2008, 47, 205–208.