Banner4
  • Home
  • Research
    • About
    • Publications
      • 2021+
      • 2017–2020
      • 2012–2016
      • 2004–2011
      • Supervised Work
    • Dissertations
  • People
    • Phil S Baran
    • Group Members
    • Former Group Members
  • Group Seminars
  • Blog
  • More…
    • Contact
    • Photos
    • Links
Facebook
Twitter

2017–2020

Home 2017–2020

2020

  • FULL TEXT
    SUPPORTING INFORMATION
    226. Hu, P.; Peters, B. K.; Malapit, C. A.; Vantourout, J. C.; Wang, P.; Li, J.; Mele, L.; Echeverria, P.-G.; Minteer, S. D.; Baran, P. S. Electroreductive Olefin-Ketone Coupling. J. Am. Chem. Soc. 2020, 142, 50, 20979–20986
  • FULL TEXT
    SUPPORTING INFORMATION
    225. Zhao, J.-X.; Chang, Y.; Elleraas, J.; Montgomery, T. P.; Spangler, J. E.; Nair, S. K.; Bel, D. M.; Gallego, G. M.; Mousseau, J. J.; Perry, M. A.; Collins, M. R.; Vantourout, J. C.; Baran, P. S. 1,2-Difunctionalized Bicyclo[1.1.1]pentanes: Long Sought After Bioisosteres for ortho/meta-Substituted Arenes. PNAS 2021, 118, e2108881118
  • FULL TEXT
    SUPPORTING INFORMATION
    224. Vantourout, J. C.; Adusumalli, S. R.; Knouse, K. W.; Flood, D. T.; Ramirez, A.; Padial, N. M.; Istrate, A.; Maziarz, K.; deGruyter, J. N.; Merchant, R. R.; Qiao, J. X.; Schmidt, M. A.; Deery, M. J.; Eastgate, M. D.; Dawson, P. E.; Bernardes, G. J. L.; Baran, P. S. Serine-Selective Bioconjugation. J. Am. Chem. Soc. 2020 142, 41, 17236–17242
  • FULL TEXT
    SUPPORTING INFORMATION
    223. Sheng, T.; Zhang, H.-J.; Shang, M.; He, C.; Vantourout, J. C.; Baran, P. S. Electrochemical Decarboxylative N‑Alkylation of Heterocycles. Org. Lett. 2020, 22, 7594-7598
  • FULL TEXT
    SUPPORTING INFORMATION
    222. Chen. L.; Barton, L. M.; Vantourout, J. C.; Xu, Y.; Chu, C.; Johnson, E. C.; Sabatini, J. J.; Baran, P. S. Electrochemical Cyclobutane Synthesis in Flow: Scaleup of a Promising Melt-Castable Energetic Intermediate. Org. Process. Res. Dev. 2020 Just Accepted
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    221. He, C.; Chu, H.; Stratton, T. P.; Kossler, D.; Eberle, K. J.; Flood, D. T.; Baran, P. S. Total Synthesis of Tagetitoxin, J. Am. Chem. Soc. 2020, 142, 13683-13688
  • FULL TEXT
    220. Kanda, Y.; Ishihara, Y.; Wilde, N.; Baran, P. S. Two-Phase Total Synthesis of Taxanes: Tactics and Strategies. J. Org. Chem. 2020, 85, 10293 - 10320
  • FULL TEXT
    SUPPORTING INFORMATION
    219. Gnaim, S.; Takahira, Y.; Wilke, H. C.; Yao, Z.; Li, J.; Delbrayelle, D.; Echeverria, P. -G.; Vantourout, J. C.; Baran, P. S. Electrochemically Driven Desaturation of Carbonyl Compounds. Nature Chem. 2021 Just Accepted
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    218. McClymont, K. S.; Wang, F-.Y.; Minakar, A.; Baran, P. S.; Total Synthesis of (–)-Maximiscin. J. Am. Chem. Soc. 2020, 142, 8608-8613.
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    217. Flood, D. T.; Knouse, K. W.; Vantourout, J. C.; Sanchez, B. B.; Sturgell, E. J.; Chen, J. S.; Baran, P. S.; Dawson, P. E. Synthetic Elaboration of Native DNA by RASS (SENDR) ACS Cent. Sci. 2020, 6, 1789 - 1799
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    216. Kanda, Y.; Nakamura, H.; Umemiya, S.; Puthukanoori, R. K.; Appala, V. R. M.; Gaddamanugu, G. K.; Paraselli, B. R.; Baran, P. S. Two-Phase Synthesis of Taxol® J. Am. Chem. Soc. 2020, 142, 10526-10533
  • FULL TEXT
    215. Kawamata, Y.; Baran, P. S. Electrosynthesis: Sustainability Is Not Enough. Joule, 2020, 4, 701-704
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    214. Flood, D. T.; Kingston, C.; Vantourout, J. C.; Dawson, P. E.; Baran, P. S. DNA Encoded Libraries: A Visitor's Guide. Isr. J. Chem. 2020, 60, 268 - 280
  • FULL TEXT
    SUPPORTING INFORMATION
    213. Xu, D.; Rivas-Bascón, N.; Padial, N. M.; Knouse, K. W.; Zheng, B.; Vantourout, J. C.; Schmidt, M. A.; Eastgate, M. D.; Baran, P. S. Enantiodivergent Formation of C–P Bonds: Synthesis of P-Chiral Phosphines and Methyl-phosphonate Oligonucleotides. J. Am. Chem. Soc. 2020, 142, 5785-5792
  • FULL TEXT
    SUPPORTING INFORMATION
    212. Flood, D. T.; Zhang, Z. Fu, Z. Zhao, Z.; Asai, S.; Sanchez, B.; Strugell, E. J.; Vantourout, J. C.; Richardson, P.; Flanagan, M. E.; Piotrowski, D. W.; Kölmel, D. K.; Wan, J.; Chang, Y.; Wang, Z.; Chen, J.; Baran, P. S.; Dawson, P. RASS-Enabled S/P–C and S–N Bond Formation for DEL Synthesis. Angew. Chem. Int. Ed. 2020, 59, 7377 - 7383
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    211. Reisberg, S. H.; Gao, Y.; Walker, A. S.; Helfrich, E. J. N.; Clardy, J.; Baran, P. S. Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A. Science 2020, 367, 458-463
  • FULL TEXT
    210. Kingston, C.; Palkowitz, M. D.; Takahira, Y.; Vantourout, J. C.; Peters, B. K.; Kawamata, Y.; Baran, P. S. A Survival Guide for the "Electro-curious" Acc. Chem. Res. 2020, 53, 72 - 83

2019

Contents

  • 2020
  • 2019
  • 2018
  • 2017
  • 2012–2016
  • 2004–2011
  • Supervised Work

  • FULL TEXT
    SUPPORTING INFORMATION
    209. Barton, L. M.; Edwards, J. T.; Johnson, E. C.; Bukowski, E. J.; Sausa, R. C.; Byrd, E. F. C.; Orlicki, J. A.; Sabatini, J. J.; Baran, P. S. Impact of Stereo- and Regiochemistry on Energetic Materials. J. Am. Chem. Soc. 2019, 141, 12531 - 12535
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    208. Xiang, J.; Shang, M.; Kawamata, Y.; Lundberg, H.; Reisberg, S.; Chen, M.; Mykhailiuk, P.; Beutner, G.; Collins, M.; Davies, A.; Del Bel, M.; Gallego, G.; Spangler, J.; Starr, J. T.; Yang, S.; Blackmond, D.; Baran, P. S. Hindered Dialkyl Ether Synthesis via Electrogenerated Carbocations. Nature 2019, 573, 398
  • FULL TEXT
    SUPPORTING INFORMATION
    207. Flood, D. T.; Asai, S.; Zhang, X.; Wang, J.; Yoon, L.; Adams, Z. C.; Dillingham, B. C.; Sanchez, B.; Vantourout, J. C.; Flanagan, M. E.; Piotrowski, D. W.; Richardson, P.; Green, S.; Shenvi, R.; Chen, J.; Baran, P. S.; Dawson, P. Expanded Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support. J. Am. Chem. Soc. 2019, 141, 9998
  • FULL TEXT
    SUPPORTING INFORMATION
    206. Ni, S.; Padial, N. M.; Kingston, C.; Vantourout, J. C.; Schmitt, D. C.; Edwards, J. T.; Kruszyk, M.; Merchant, R. R.; Mykhailiuk, P. K.; Sanchez, B.; Yang, S.; Perry, M.; Gallego, G. M.; Mousseau, J. J.; Collins, M. R.; Cherney, R. J.; Lebed, P. S.; Chen, J. S.; Qin, T.; Baran, P. S. A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines. J. Am. Chem. Soc. 2019, 141, 6726.
  • FULL TEXT
    SUPPORTING INFORMATION
    205. Takahira, Y.; Chen, M.; Kawamata, Y.; Mykhailiuk, P.; Nakamura, H. Peters, B. K.; Reisberg, S. H.; Li, C.; Chen, L.; Hoshikawa, T.; Shibuguchi, T.; Baran, P. S. Electrochemical C(sp3)-H Fluorination. Synlett, 2019, 30, 1178
  • FULL TEXT
    SUPPORTING INFORMATION
    204. Kawamata, Y.; Vantourout, J. C.; Hickey, D. P.; Bai, P.; Chen, L.; Hou, Q.; Qiao, W.; Barman, K.; Edwards, M. A.; Garrido-Castro, A. F.; deGruyter, J. N.; Nakamura, H.; Knouse, K.; Qin, C.; Clay, K. J.; Bao, D.; Li, C.; Starr, J. T.; Garcia-Irizarry, C.; Sach, N.; White, H. S.; Neurock, M.; Minteer, S. D.; Baran, P. S. Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications. J. Am. Chem. Soc. 2019, 141, 6392.
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    203. Peters, B. K.; Rodriguez, K. X., Reisberg, S. H.; Beil, S. B.; Hickey, D. P.; Kawamata, Y.; Collins, M.; Starr, J.; Chen, L.; Udyavara, S.; Klunder, K.; Gorey, T. J.; Anderson, S. L.; Neurock, M.; Minteer, S. D.; Baran, P. S. Scalable and Safe Synthetic Organic Electroreduction Inspired by Li-Ion Battery Chemistry. Science 2019, 363, 838
  • FULL TEXT
    SUPPORTING INFORMATION
    202. Shang, M.; Feu, K. S.; Vantourout, J. C.; Barton, L. M.; Osswald, H. L.; Kato, N.; Gagaring, K.; McNamara, C. W.; Chen, G.; Hu, L.; Ni, S.; Fernández-Canelas, P.; Chen, M.; Merchant, R. R.; Qin, T.; Schreiber, S.; Melillo, B.; Yu, J.-Q.; Baran, P. S. Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids. PNAS, 2019, 116, 8721
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    201. Nakamura, H.; Yasui, K; Kanda, Y.; and Baran, P. S. 11-Step Total Synthesis of Teleocidins B-1–B-4. J. Am. Chem. Soc. 2019, 141, 1494.
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    200. Chen, T. -G.; Zhang, H.; Mykhailiuk, P. K.; Merchant, R. R.; Smith, C. A.; Qin, T.; Baran, P. S. Quaternary Centers via Ni-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and Aryl Zinc Reagents. Angew. Chem. Int. Ed. 2019, 58, 2454.
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    199. He, C.; Stratton, T. P.; Baran, P. S. Concise Total Synthesis of Herqulines B and C. J. Am. Chem. Soc. 2019, 141, 29.
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    198. Kingston, C.; Wallace, M; Allentoff, A. J.; deGruyter, J.; Chen, J.; Gong, S.; Bonacorsi, S. Jr.; Baran, P. S. Direct Carbon Isotope Exchange Through Decarboxylative Carboxylation. JACS, 2019, 141, 2, 774.

2018

  • FULL TEXT
    197. Smith, J.; Dixon, J.; deGruyter, J. N.; Baran, P. S. Alkyl Sulfinates: Radical Precursors Enabling Drug Discovery. J. Med. Chem. 2018, 62, 2256
  • FULL TEXT
    SUPPORTING INFORMATION
    196. Ni, S.; Garrido-Castro, A. F.; Merchant, R. R.; deGruyter, J. N.; Schmitt, D. C.; Mousseau, J. J.; Gallego, G. M.; Yang, S.; Collins, M. R.; Qiao, J. X.; Yeung, K.; Langley, D. R.; Poss, M. A.; Scola, P. M.; Qin, T.; Baran, P. S. A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling, Angew. Chem. Int. Ed. 2018, 57, 14560.
  • FULL TEXT
    SUPPORTING INFORMATION
    195. Wang, J.; Shang, M.; Lundberg, H.; Feu, K. S.; Hecker, S. J.; Qin, T.; Blackmond, D. G.; Baran, P. S. Cu-Catalyzed Decarboxylative Borylation. ACS Catal. 2018, 8, 9537.
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    194. Knouse, K. W.; deGruyter, J. N.; Schmidt, M. A.; Zheng, B.; Vantourout, J. C.; Kingston, C.; Mercer, S. E.; Mcdonald, I. M.; Olson, R. E.; Zhu, Y.; Hang, C.; Zhu, J.; Yuan, C.; Wang, Q.; Park, P.; Eastgate, M. D.; Baran, P. S. Unlocking P(V): Reagents for chiral phosphorothioate synthesis. Science, 2018, 361, 1234
  • FULL TEXT
    193. Smith, J. M.; Harwood, S. J.; Baran, P. S. Radical Retrosynthesis. Acc. Chem. Res. 2018, 51, 1807.
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    192. Chen, T. –G.; Barton, L. M.; Lin, Y.; Tsien, J.; Kossler, D.; Bastida, I.; Asai, S.; Bi, C.; Chen, J. S.; Shan, M.; Fang, H.; Fang, F. G.; Choi, H. –W.; Hawkins, L.; Qin, T.; Baran, P. S. Building C(sp3)-rich complexity by combining cycloaddition and C–C cross-coupling reactions. Nature, 2018, 560, 350-354.
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    191. Merchant, R. R.; Oberg, K. M.; Lin, Y.; Novak, A. J. E.; Felding, J.; Baran, P. S. Divergent Synthesis of Pyrone Diterpenes via Radical Cross Coupling. J. Am. Chem. Soc. 2018, 140, 7462.
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    190. Wang, J.; Lundberg, H.; Asai, S.; Martín-Acosta, P.; Chen, J. S.; Brown, S.; Farrell, W.; Dushin, R.; O’Donnell, C. J.; Ratnayake, A. S.; Richardson, P.; Liu, Z.; Qin, T.; Blackmond, D. G.; Baran, P. S. Kinetically Guided Radical-Based Synthesis of C(sp3)-C(sp3) Linkages on DNA. PNAS, 2018, 115, E6404.
  • FULL TEXT
    189. Baran, P. S. Natural Product Total Synthesis: As Exciting as Ever and Here To Stay. J. Am. Chem. Soc. 2018, 140, 4751.
  • FULL TEXT
    SUPPORTING INFORMATION
    188. Chu, H.; Dünstl, G.; Felding, J.; Baran, P. S. Divergent synthesis of thapsigargin analogs. Bioorg. Med. Chem. Lett. 2018, Bioorg. Med. Chem. Lett. 2018, 28, 2705.
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    187. Peters, D.; Romesberg, F. E.; Baran, P. S. Scalable Access to Arylomycins via C–H Functionalization Logic. J. Am. Chem. Soc. 2018, 140, 2072.
  • FULL TEXT
    Blog post
    SUPPORTING INFORMATION
    186. Merchant, R. R.; Edwards, J. T.; Qin, T.; Kruszyk, M. M.; Bi, C.; Che, G.; Bao D-H.; Qiao, W.; Sun, L.; Collins, M. R.; Gallego, G. M.; Mousseau, J. J.; Nuhant, P.; Baran, P. S. Modular radical cross-coupling with sulfones enables access to sp3-rich (fluoro)alkylated scaffolds. Science, 2018, 360, 75.

2017